Benzimidazole definition of benzimidazole by merriamwebster. Pages in category benzimidazoles the following 89 pages are in this category, out of 89 total. Synthetic approaches to benzimidazoles from o phenylenediamine. Benzimidazoles pharmacology merck veterinary manual. Benzimidazoles are frequently used as veterinary medicines mostly anthelmintics, and many feature prominently in pharmaceuticals. Synthesis, characterization, and biological evaluation of. Benzimidazoles eg, fenbendazole, flubendazole show high efficacy against both adult and immature stages of ascaris suum. Bencimidazoles antiparasitarios internos terapeutica veterinaria. Benzimidazole definition of benzimidazole by medical dictionary. Benzimidazoles heterocyclic building blocks sigmaaldrich. This raises the ques tion as to why benzimidazoles can selec tively kill helminths and yet exhibit little or no mammalian toxicity. Udc, multicomponent reactions mcrs, benzimidazoles, bis benzimidazoles, bisbenzimidazoledihydroquinoxalines introduction isocyanidebased multicomponent reactions imcrs, and their applications, in which three or more starting materials combine to form a single highly functionalized product, have witnessed a resurgence of. Descargue como docx, pdf, txt o lea en linea desde scribd.
Various n aryl1 h indazoles and benzimidazoles were synthesized from common arylamino oximes in good to excellent yields depending upon the base used in the reaction. Benzimidazoles are also highly effective against most other swine nematodes. In continuation, on the synthesis of heterocycles,14 and on the development of synthetic methodologies,1517 we herein report a facile method for the synthesis of benzimidazoles by the condensation of 1, 2phenylenediamine with carbonyl compounds, in the presence of ammonium salts in very good yields. Benzimidazole, a heterocyclic aromatic organic compound consisting of a fusion of benzene and imidazole, in an extension of the wellelaborated imidazole system, has been used as a carbon skeleton for n heterocyclic carbenes, usually used as ligand for transition metal complexes. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. In dogs and cats, mebendazole, fenbendazole, febantel, oxfendazole, oxibendazole, and flubendazole are used for treatment of roundworms, hookworms. The standard synthesis for benzimidazoles is the cyclocondensation of ophenylenediamine or substituted ophenylenediamines with carboxylic acids or their derivatives.
Antiparasiticagents, benzimidazoles, mebendazole, atovaquone, thiabendazole, albendazole benzimidazoles. Pharmacological compounds of benzimidazole derivatives are potent inhibitors for a variety of enzymes. A ring system composed of a benzene ring fused with an imidazole ring. A class of antihelmintic, often used to treat nematodes and cestodes. It is a tautomer of a 4hbenzimidazole, a 2hbenzimidazole and a 3ahbenzimidazole. Benzimidazole is produced by condensation of ophenylenediamine with formic acid, or the equivalent trimethyl orthoformate. Guerre benzimidazoles anthelminthiques 21 2spectre et doses therapeutiques mgkg triclabend. The compounds were also tested for the inhibition of rat brain tubulin polymerization and compared with standard drug. Benzimidazoles were syntheized from ophenylenediamines and aliphatic acids.
It is a benzimidazole and a polycyclic heteroarene. Benzimidazoles article about benzimidazoles by the free. Benzimidazole definition is a crystalline base c7h6n2 that is composed of a benzene ring fused with an imidazole ring and is structurally similar to purine. Lacey benzimidazoles represent the only class of truly broadspectrum anthelmintics, how ever, they also show activity against fungi and mammalian cells. Facile, novel twostep syntheses of benzimidazoles, bis. Various 1h benzimidazoles 71 have been synthesized and tested in vitro against the protozoa g. Triethylamine promoted the formation of benzimidazoles, whereas 2aminopyridine promoted the formation of n arylindazoles. Benomil, carbendazim, metil tiofanato, tiabendazol, fuberidazol. Benzimidazoles definition of benzimidazoles by medical.
228 1496 223 994 1519 436 17 391 754 1281 1504 36 705 447 300 1227 1172 319 917 1072 309 470 482 1487 88 463 284 227 1408 271 1340 724 684 499 17 1435 250 1237